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Caution should be used when prescribing fenofibrates with VYTORINas these agents can cause myopathy when given alone and the risk is increased when they are coadministeredsee DRUG INTERACTIONS

Simvastatin is in a group of drugs called HMG CoA reductase inhibitorsorstatins

Generic Nameezetimibe and simvastatinez ET i mibe and SIM va stat inBrand NamesVytorin.

VYTORIN therapy should be discontinued if markedly elevated CPK levels occur or myopathy is diagnosed or suspectedVYTORIN therapy should also be temporarily withheld in any patient experiencing an acute or serious condition predisposing to the development of renal failure secondary to rhabdomyolysise.gsepsishypotensionmajor surgerytraumasevere metabolicendocrineor electrolyte disordersor uncontrolled epilepsy.

The safety and effectiveness of VYTORIN administered with fibrates have not been establishedBecause it is known that the risk of myopathy during treatment with HMG-CoA reductase inhibitors is increased with concurrent administration of fenofibratesVYTORIN should be administered with caution when used concomitantly with a fenofibratesee WARNINGS AND PRECAUTIONS

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