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It is recommended that patients initiate oral therapy with Prograf capsules if possibleInitial dosage and observed tacrolimus whole blood trough concentrations for adults are shown in Table 1 and for pediatrics in Table 3see Dosage In Adult KidneyLiverOr Heart Transplant Patientsfor blood concentration monitoring details in kidney transplant patientssee Dosage In Adult KidneyLiverOr Heart Transplant Patients

Due to the chemical instability of tacrolimus in alkaline mediaPrograf injection should not be mixed or co-infused with solutions of pH 9 or greatere.gganciclovir or acyclovir

Tell your doctor right away if you develop any of the followingunusual skin changeschange in the appearance/size of molesunusual growths/lumpsswollen glandsnight sweatsunexplained weight losssigns of infectione.gfeverpersistent sore throat

Before you take PROGRAFtell your healthcare provider about all of your medical conditionsincluding if youplan to receive any live vaccinespeople taking PROGRAF should not receive live vaccineshave or have had liverkidney or heart problems are pregnant or plan to become pregnantPROGRAF can harm your unborn babyIf you are able to become pregnantyou should use effective birth control before and during treatment with PROGRAFTalk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for youMales who have female partners who are able to become pregnant should also use effective birth control before and during treatment with PROGRAFTalk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for youare breastfeeding or plan to breastfeedPROGRAF passes into your breast milkYou and your healthcare provider should decide if you will breastfeed while taking PROGRAF.

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if possible, initiating oral therapy with prograf capsules is recommended.