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CardiovascularHypotension including orthostatic hypotensionmay be aggravated by alcoholbarbituratesnarcotics or antihypertensive drugs

Edema during pregnancy may arise from pathological causes or from the physiologic and mechanical consequences of pregnancyDiuretics are indicated in pregnancy when edema is due to pathologic causesjust as they are in the absence of pregnancyDependent edema in pregnancy resulting from restriction of venous return by the expanded uterus is properly treated through elevation of the lower extremities and use of support hoseuse of diuretics to lower intravascular volume in this case is illogical and unnecessaryThere is hypervolemia during normal pregnancy which is harmful to neither the fetus nor the motherin the absence of cardiovascular diseasebut which is associated with edemaincluding generalized edema in the majority of pregnant womenIf this edema produces discomfortincreased recumbency will often provide reliefIn rare instances this edema may cause extreme discomfort which is not relieved by restIn these cases a short course of diuretics may provide relief and may be appropriate.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

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Avalide or irbesartan hydrochlorothiazide should never be used during pregnancy without consulting the doctor.

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