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If you are taking colchicine to prevent gout attackscall your doctor right away if you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.

Digestiveabdominal crampingabdominal paindiarrhealactose intolerancenauseavomiting.

Colchicine is a substrate for both CYP3A4 and the transport protein P-gpIn the presence of CYP3A4 or P-gp inhibitorsthe concentrations of colchicine in the blood increaseToxicityincluding fatal caseshave been reported during concurrent use of CYP3A4 or P-gp inhibitors such as macrolidesclarithromycin and erythromycinciclosporinketoconazoleitraconazolevoriconazoleHIV protease inhibitorscalcium channel blockersverapamil and diltiazemand disulfiramsee section 4.4

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Some patients who require small doses of prednisone, to maintain safe platelet counts, can be successfully switched to either colchicine 0.

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Examples include certain azole antifungals such as itraconazole, ketoconazole, posaconazole, voriconazole , boceprevir, cobicistat, colchicine, delavirdine, macrolide antibiotics such as clarithromycin, erythromycin , nefazodone, hiv protease inhibitors such as nelfinavir, ritonavir , telaprevir, telithromycin, among others.

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With orchids, colchicine is used in sterile tissue culture.

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In addition, patients in the icap study likely received excellent counseling about colchicine s side effects and did, in fact, have the benefit of close clinical and biochemical monitoring for toxic effects.

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