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Patients who wear contact lenses should be cautioned that treatment with CATAPRES tablets may cause dryness of eyes.

Tolerance to the antihypertensive effect may develop in some patientsnecessitating a reevaluation of therapy.

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In combination with amitriptylineclonidine hydrochloride administration led to the development of corneal lesions in rats within 5 days.

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many experts theorize that by adding clonidine to a psychostimulant, the combination elicits a synergistic effect most notably in the prefrontal cortex.