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May cause acute renal failure including tubulointerstitial nephritisdiscontinue therapy if renal failure occurs and initiate supportive therapy.

Several cephalosporins have been implicated in triggering seizuresparticularly in patients with renal impairment when the dosage was not reducedsee DOSAGE AND ADMINISTRATION and OVERDOSAGEIf seizures associated with drug therapy occurthe drug should be discontinuedAnticonvulsant therapy can be given if clinically indicated.

Safety in pregnancy has not been established for cefiximeThere are no adequate studies in pregnant womenhoweverstudies in animals suggest no important effects on the fetus.

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