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Cases of hyperglycemia have been reported with sucralfateBezoars have been reported in patients treated with sucralfateThe majority of patients had underlying medical conditions that may predispose to bezoar formationsuch as delayed gastric emptyingor were receiving concomitant enteral tube feedings.

Due to limited experience in humans with overdosage of sucralfateno specific treatment recommendations can be givenAcute oral studies in animalshoweverusing doses up to 12 g/kg body weightcould not find a lethal doseSucralfate is only minimally absorbed from the gastrointestinal tractRisks associated with acute overdosage shouldthereforebe minimalIn rare reports describing sucralfate overdosemost patients remained asymptomaticThose few reports where adverse events were described included symptoms of dyspepsiaabdominal painnauseaand vomiting.

When sucralfate is administered orallysmall amounts of aluminum are absorbed from the gastrointestinal tractConcomitant use of sucralfate with other products that contain aluminumsuch as aluminum-containing antacidsmay increase the total body burden of aluminumPatients with normal renal function receiving the recommended doses of sucralfate and aluminum-containing products adequately excrete aluminum in the urinePatients with chronic renal failure or those receiving dialysis have impaired excretion of absorbed aluminumIn additionaluminum does not cross dialysis membranes because it is bound to albumin and transferrin plasma proteinsAluminum accumulation and toxicityaluminum osteodystrophyosteomalaciaencephalopathyhave been described in patients with renal impairmentSucralfate should be used with caution in patients with chronic renal failure.

Take sucralfate on an empty stomachat least 1 hour before or 2 hours after a meal.

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