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Th occunc hypsnsitivity actions tZYLOPIM (allopuinol) may b incasd in patints with dcasd nal unction civing thiazids and ZYLOPIM (allopuinol) concuntly. this ason, in this clinical stting, such combinations should b administd with caution and patints should b obsvd closly.

Stop using allopuinol and call you doctat onc i you hav a sious sid ct such as:

B caul whn dinking alcohol whil you a taking this mdicin. I you dink alcohol, dowsinss, dizzinss and blud vision may b wos.

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6 mg po daily to twice daily allopurinol 100-300 mg day use lowest dose to keep uric acid 6 mg dl 5 mg dl if symptomatic probenacid may be used in combination with allopurinol if gfr 50 ml min and normal urine uric acid normal duzallo allopurinol with lesinurad is an expensive alternative to probenacid and allopurinol initiating dose start 100 mg daily for 2 weeks next 200 mg daily for 2 weeks next 300 mg daily most effective dose for most patients some patients require higher doses up to 800 mg day to maintain uric acid 6 mg dl adjust for renal function gfr 90 ml min 300 mg daily gfr 60-89 ml min 200 mg daily gfr 30-59 ml min 100 mg daily gfr 10-29 ml min or cr 1.