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Figure 5 Kaplan-Meier Estimates of Survival XELODA and Docetaxel vs Docetaxel.

Lactating mice given a single oral dose of capecitabine excreted significant amounts of capecitabine metabolites into the milkIt is not known whether this drug is excreted in human milkBecause many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from capecitabinea decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.

You have blood tests before starting treatment and during your treatmentThey check your levels of blood cells and other substances in the bloodThey also check how well your liver and kidneys are working.

Care should be exercised in the handling of XELODAXELODA tablets should not be cut or crushedProcedures for the proper handling and disposal of anticancer drugs should be consideredAny unused product should be disposed of in accordance with local requirementsor drug take back programsSeveral guidelines on the subject have been published.

Enzymes convert capecitabine to 5-fluorouracil5-FUin vivoBoth normal and tumor cells metabolize 5-FU to 5-fluoro-2deoxyuridine monophosphateFdUMPand 5-fluorouridine triphosphateFUTPThese metabolites cause cell injury by two different mechanismsFirstFdUMP and the folate cofactorNmethylenetetrahydrofolatebind to thymidylate synthaseTSto form a covalently bound ternary complexThis binding inhibits the formation of thymidylate from 2deoxyuridylateThymidylate is the necessary precursor of thymidine triphosphatewhich is essential for the synthesis of DNAso that a deficiency of this compound can inhibit cell divisionSecondnuclear transcriptional enzymes can mistakenly incorporate FUTP in place of uridine triphosphateUTPduring the synthesis of RNAThis metabolic error can interfere with RNA processing and protein synthesis.

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so it seems that most of you in the group have already had radiation or will have radiation prior to starting xeloda.