We confirmed that colchicine had no long-term effects on tumor growth by preparing histological sections of tumors 20 days after initiation and staining for proliferative cell nuclear antigen pcna .

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If you are taking colchicine to prevent gout attackscall your doctor right away if you experience a gout attack during your treatmentYour doctor may tell you to take an extra dose of colchicinefollowed by a smaller dose one hour laterIf you take extra doses of colchicine to treat a gout attackyou should not take your next scheduled dose of colchicine until at least 12 hours have passed since you took the extra doses.

Digestiveabdominal crampingabdominal paindiarrhealactose intolerancenauseavomiting.

Colchicine is a substrate for both CYP3A4 and the transport protein P-gpIn the presence of CYP3A4 or P-gp inhibitorsthe concentrations of colchicine in the blood increaseToxicityincluding fatal caseshave been reported during concurrent use of CYP3A4 or P-gp inhibitors such as macrolidesclarithromycin and erythromycinciclosporinketoconazoleitraconazolevoriconazoleHIV protease inhibitorscalcium channel blockersverapamil and diltiazemand disulfiramsee section 4.4

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